- AnovaOS™ will be used to support site activation, patient identification and enrolment through just-in-time approach;
- AnovaOS™ will be used to support the delivery of two studies of DZD9008 for patients with advanced or metastatic NSCLC harboring EGFR Exon20 insertion mutation (Exon20ins) in a Phase III study study in a first-line setting and a Phase II study in ≥ 2nd line setting;
- Patients with lung cancer and a epidermal growth factor receptor (EGFR) exon 20 insertion mutation meet study specific eligibility criteria can participate in the studies where they choose to receive care.
Anova today announced a partnership with Dizal Pharmaceuticals (Dizal) to accelerate the development of DZD9008 for patients with EGFR Exon20ins mutant NSCLC.
Dizal is a commercial-stage biopharmaceutical company focused on the discovery and development of differentiated therapeutics for the treatment of cancer and immunological diseases. Dizal are evaluating DZD9008 in a Phase III study in a first-line setting and a Phase II study in a recurrent setting.
EGFR Exon20ins occur in about 2% patients with NSCLC. No target therapy has gained full approval for the treatment. Chemotherapy is the most commonly used in the first-line setting, but the treatment’s efficacy is not optimal. Therefore, there is an unmet medical need to develop more effective therapy.
“Advances in precision medicine have clearly helped patients with EGFR mutations survive longer. Anova and Dizal are committed to building upon recent success with DZD9008 following NDA approval of Sunvozernitib for the treatment of adult patients with locally advanced or metastatic NSCLC patients with EGFR Exon20ins by the National Medical Products Administration (NMPA) of China. We are identifying the underserved group of NSCLC cases that have EGFR Exon20ins mutations and giving them an opportunity to participate in research designed to benefit them.
“It is not enough to identify patients with rare tumor mutations and hope they can access a promising clinical trial,” said Martin Walsh, President at Anova. “AnovaOS™ provides a network that allows any patient to participate in research where they choose to receive care. Being able to deliver study opportunities in real time transforms the way research has been historically conducted.”
Research sites and physicians interested in participating in this study should register their profile at www.anovaevidence.com. NSCLC patients with EGFR Exon20ins mutations can e-mail Dizal@anovaevidence.com to find out more about the study and consider participation. To find out more contact Victor Sirippi, Project Lead at victor@anovaevidence.com
